![]() ![]() The following represents MIC susceptibility data for a few medically significant pathogens. A notable exception is Capnocytophaga canimorsus, for which clindamycin is a first-line drug of choice. Most aerobic Gram-negative bacteria (such as Pseudomonas, Legionella, Haemophilus influenzae and Moraxella) are resistant to clindamycin, as are the facultative anaerobic Enterobacteriaceae. Anaerobic, Gram-negative rod-shaped bacteria, including some Bacteroides, Fusobacterium, and Prevotella, although resistance is increasing in Bacteroides fragilis.pneumococcus) genera, but not enterococci. Aerobic Gram-positive cocci, including some members of the Staphylococcus and Streptococcus ( e.g.It is most effective against infections involving the following types of organisms: Topical clindamycin plus topical benzoyl peroxide is more effective than topical clindamycin alone. Acne Clindamycin phosphate topical solutionįor the treatment of acne, in the long term, the combined use of topical clindamycin and benzoyl peroxide was similar to salicylic acid plus benzoyl peroxide. Topical application of clindamycin phosphate can be used to treat mild to moderate acne. It is also used to treat bone and joint infections, particularly those caused by Staphylococcus aureus. In people with hypersensitivity to penicillins, clindamycin may be used to treat infections caused by susceptible aerobic bacteria, as well. Medical uses Ĭlindamycin is used primarily to treat anaerobic infections caused by susceptible anaerobic bacteria, including dental infections, and infections of the respiratory tract, skin, and soft tissue, and peritonitis. In 2020, it was the 125th most commonly prescribed medication in the United States, with more than 5 million prescriptions. It is on the World Health Organization's List of Essential Medicines. Ĭlindamycin was first made in 1966 from lincomycin. It is of the lincosamide class and works by blocking bacteria from making protein. It appears to be generally safe in pregnancy. ![]() Alternative antibiotics may be recommended as a result. It increases the risk of hospital-acquired Clostridium difficile colitis about fourfold and thus is only recommended when other antibiotics are not appropriate. Ĭommon side effects include nausea and vomiting, diarrhea, rashes, and pain at the site of injection. It is available by mouth, by injection into a vein, and as a cream or a gel to be applied to the skin or in the vagina. In combination with quinine, it can be used to treat malaria. It can also be used to treat acne, and some cases of methicillin-resistant Staphylococcus aureus (MRSA). Clindamycin is an antibiotic medication used for the treatment of a number of bacterial infections, including osteomyelitis (bone) or joint infections, pelvic inflammatory disease, strep throat, pneumonia, acute otitis media (middle ear infections), and endocarditis. ![]()
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